Permeability of tritiated water through human cervical and vaginal tissue
| Autor: | Kristy D. McCullough, Marilyn Cost, Alexandra B. Sassi, Lisa C. Rohan, Sharon L. Hillier |
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| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty Apparent permeability Passive transport Tritiated water Anti-HIV Agents Administration Topical Human immunodeficiency virus (HIV) Pharmaceutical Science Physiology Cervix Uteri Tritium medicine.disease_cause Permeability chemistry.chemical_compound Freezing medicine Humans business.industry Water Cervical tissue Vaginal tissue Permeability (earth sciences) chemistry Vagina Female Delivery system business |
| Zdroj: | Journal of Pharmaceutical Sciences. 93:2009-2016 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.20107 |
| Popis: | The increased incidence of human immunodeficiency virus infection in women has identified an urgent need to develop a female-controlled method to prevent acquisition of human immunodeficiency virus and other sexually transmitted diseases. Women would apply the product intravaginally before intercourse. Development of such a product requires a better understanding of the permeability characteristics of the tissues with which such products would come into contact. However, limited studies have been performed in this area. In the present study, water permeability of fresh human cervical and vaginal tissue was evaluated. The average apparent permeability coefficient was found to be 8 × 10 −5 cm/s for fresh human cervical tissue and 7 × 10 −5 cm/s for fresh human vaginal tissue. Considering the lack of regularity in obtaining cervical and vaginal tissue from surgical specimens, additional tests were performed to evaluate the effect of freezing on tritiated water permeability. No statistically significant differences were observed in the permeability values obtained when comparing fresh versus frozen tissues. |
| Databáze: | OpenAIRE |
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