Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia
| Autor: | Brian D. Zelickson, Suzanne L. Kilmer, Girish S. Munavalli, Lauren Jauregui, Edward Ebbers, Thomas E. Rohrer, Richard Nuccitelli, Mona M. Selim, Darrin Uecker, James Newman, William A Knape |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class SEBACEOUS GLAND HYPERPLASIA Electric Stimulation Therapy Dermatology Severity of Illness Index law.invention Sebaceous Glands 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermis Randomized controlled trial law Photography Humans Medicine Prospective Studies Prospective cohort study Aged Hyperplasia business.industry Local anesthetic General Medicine Middle Aged Nanosecond Hyperpigmentation Treatment Outcome medicine.anatomical_structure Tolerability 030220 oncology & carcinogenesis Original Article Female Surgery Radiology medicine.symptom business Follow-Up Studies |
| Zdroj: | Dermatologic Surgery |
| ISSN: | 1524-4725 1076-0512 0361-2570 |
| Popis: | Background Nanosecond pulsed electric field (nsPEF) technology involves delivery of ultrashort pulses of electrical energy and is a nonthermal, drug-free technology that has demonstrated favorable effects on cellular structures of the dermis and epidermis. Objective Determine the tolerability and effectiveness of nsPEF treatment of sebaceous gland hyperplasia (SGH). Methods This study was a prospective, randomized, open-label, multisite, nonsignificant risk trial in which each subject served as their own control. After injection of local anesthetic, high-intensity, ultrashort pulses of electrical energy were used to treat 72 subjects resulting in a total of 222 treated lesions. Subjects returned for 3 to 4 follow-up evaluations with photographs. Results At the final study visit, 99.6% of treated SGH lesions were rated clear or mostly clear and 79.3% of the subjects were satisfied or mostly satisfied with the outcome. At 60 days after nsPEF treatment, 55% of the lesions were judged to have no hyperpigmentation and 31% exhibited mild post-treatment hyperpigmentation. At the last observation for all lesions, 32% of the 222 lesions were noted as having slight volume loss. Conclusion Nanosecond pulsed electric field procedure is well tolerated and is very effective in the removal of SGHs. Trial registration ClinicalTrials.gov NCT03612570. |
| Databáze: | OpenAIRE |
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