Investigation of the Relationship between CMYC Gene Polymorphisms and Glioma Susceptibility in Chinese Children

Autor: Jingying Zhou, Juxiang Wang, Ao Lin, Zhen Wang, Li Yuan, Jichen Ruan, Hanqi Dai, Xiaoqian Tian, Susu Lou, Xiaokai Huang
Rok vydání: 2021
Předmět:
DOI: 10.6084/m9.figshare.15081507.v2
Popis: Glioma is a common central nervous system tumors in children. CMYC has a range of functions that are disrupted in various tumor cells, and may contribute to the occurrence and development of glioma. Two CMYC single nucleotide polymorphisms (rs4645943C > T and rs2070583 A > G) were genotyped in 190 cases and 248 controls from Wenzhou and Guangzhou hospitals. After adjusting for age and sex, odds ratio and 95% confidence interval values were calculated by logistic regression to evaluate the correlation between CMYC gene polymorphisms and glioma risk; no significant associations were detected. These results require future validation in a larger sample cohort.
Databáze: OpenAIRE