Comparison of meperidine plus midazolam and fentanyl plus midazolam in procedural sedation: a double-blind, randomized controlled trial
| Autor: | Hakan Topacoglu, Kazim Tirpan, Ali Günerli, Ahmet Demircan, Ozgur Karcioglu, Niyazi Ozucelik, Mustafa Serinken, Suna Soysal |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Meperidine medicine.drug_class Visual analogue scale Sedation Midazolam Analgesic Conscious Sedation Joint Dislocations law.invention Fentanyl Fractures Bone Randomized controlled trial Double-Blind Method law medicine Humans Hypnotics and Sedatives Pharmacology (medical) Adverse effect Pain Measurement business.industry General Medicine Middle Aged Surgery Analgesics Opioid Sedative Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | Advances in therapy. 21(5) |
| ISSN: | 0741-238X |
| Popis: | This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for reduction were randomized to receive fentanyl (1 mcg/kg; n = 36) or meperidine (0.5 mg/kg; n = 34) in combination with midazolam (0.02 mg/kg). Vital signs and alertness scale scores of the patients were monitored. The Visual Analog Scale (VAS) was used to determine the degree of pain. There was no statistically significant difference between the VAS mean scores of the fentanyl and meperidine groups (t test, P = .772). The need for additional analgesic drugs was significantly more frequent in patients receiving meperidine (P = .018). No adverse events, such as hypotension or respiratory depression, were noted. Euphoria occurred in one patient in the fentanyl group. Although dose requirements differ, fentanyl and meperidine provide effective and reliable analgesia in closed reduction of fractures and dislocations. |
| Databáze: | OpenAIRE |
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