Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers
| Autor: | H.-J. Siemens, Y. Gaber, W. Schmeller |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Postphlebitic Syndrome Dermatology Gastroenterology Varicose Ulcer Risk Factors Internal medicine Epidemiology medicine Factor V Leiden Humans Point Mutation Genetic Predisposition to Disease Activated Protein C Resistance Aged biology business.industry Point mutation Factor V Middle Aged medicine.disease Thrombosis Surgery biology.protein Female Activated protein C resistance business Protein C medicine.drug Post-thrombotic syndrome |
| Zdroj: | British Journal of Dermatology. 144:546-548 |
| ISSN: | 1365-2133 0007-0963 |
| Popis: | Background Activated protein C (APC) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis. Objectives To determine the prevalence of APC resistance due to factor V Leiden mutation in patients with leg ulcers. Methods Within a 2-year-period 100 consecutive patients with leg ulcers were examined for factor V Leiden mutation. Results APC resistance due to factor V Leiden mutation was detected in 19 of 53 patients (36%) with post-thrombotic leg ulcers and in three of 47 patients (6%) with ulcers caused by primary varicosis. In a healthy control group APC resistance due to factor V Leiden mutation was found in five of 96 (5%) volunteers. Conclusions In view of this high prevalence of APC resistance of 36%, which has never previously been reported, patients with post-thrombotic leg ulcers should be investigated for APC resistance. |
| Databáze: | OpenAIRE |
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