Coagulation inhibitors and fibrinolytic parameters in patients on peritoneal dialysis and haemodialysis
| Autor: | H. Abu Aisha, A.K. Al-Momen, Jamal Al-Wakeel, S. Hurieb, Ahmed H Mitwalli, A. M. A. Gader |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Adolescent Urology medicine.medical_treatment Antithrombin III Gastroenterology Protein S Peritoneal dialysis Peritoneal Dialysis Continuous Ambulatory Renal Dialysis Internal medicine Fibrinolysis Humans Medicine In patient Aged Diminution business.industry Continuous ambulatory peritoneal dialysis Middle Aged Surgery Plasminogen Inactivators Coagulation Tissue Plasminogen Activator Kidney Failure Chronic Female business Protein C medicine.drug |
| Zdroj: | International Urology and Nephrology. 28:255-261 |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/bf02550871 |
| Popis: | Coagulation inhibitors and fibrinolytic parameters were studied in twelve patients on continuous ambulatory peritoneal dialysis (CAPD) and ten patients on haemodialysis (HD). Patients on CAPD exhibited higher levels of ATIII and proteins C and S than those on HD. No significant differences were noted in tPA and PAI levels. Both groups of patients showed higher levels of tPA than controls. Besides, patients on HD had significantly lower levels of ATIII and protein C than controls. PAI levels in both patients groups were similar to those of the controls, but tPA levels were higher in patients than in controls. These results indicate that HD is associated with marked diminution in the circulating levels of coagulation inhibitors. This is in contrast to CAPD patients who showed elevated levels of these inhibitors, despite their significant loss in the dialysate. The finding of enhanced fibrinolysis in both patient groups may be a natural protective mechanism against the development of a thrombotic tendency. |
| Databáze: | OpenAIRE |
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