Development of high-grade osteosarcoma in a patient with recurrent giant cell tumor of the ischium while receiving treatment with denosumab
| Autor: | Alberto Righi, Shinji Tsukamoto, Kanya Honoki, Davide Maria Donati, Daniel Vanel, Costantino Errani |
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| Přispěvatelé: | Tsukamoto, Shinji, Righi, Alberto, Vanel, Daniel, Honoki, Kanya, Donati, Davide Maria, Errani, Costantino |
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Bone Density Conservation Agent Biopsy medicine.medical_treatment Bone Neoplasms Bone Neoplasm Malignant transformation 03 medical and health sciences Osteosclerosis 0302 clinical medicine Ischium Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Giant Cell Tumor of Bone Osteosarcoma Chemotherapy Bone Density Conservation Agents business.industry General Medicine Malignancy in giant cell tumor of bone medicine.disease Curettage Radiation therapy Cell Transformation Neoplastic 030104 developmental biology Denosumab 030220 oncology & carcinogenesis Female Radiology Neoplasm Recurrence Local business Human medicine.drug Giant-cell tumor of bone |
| Zdroj: | Japanese Journal of Clinical Oncology. 47:1090-1096 |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/hyx112 |
| Popis: | Malignant transformation of giant cell tumor of bone (GCTB) without radiotherapy exposure is exceptionally rare, occurring in less than 1% of GCTBs. The safety and efficacy of denosumab in patients with GCTB was recently reported. We herein report a case of a benign recurrent GCTB with an H3F3A mutation that underwent secondary malignant transformation during treatment with denosumab. A 29-year-old woman underwent curettage of a GCTB of the left ischium in 2005. Ten years after the first surgery, the GCTB recurred locally. We started treatment with denosumab. During the first 5 months of treatment, we observed a demarcated area of osteosclerosis in the recurrent lesion, and the patient's clinical condition improved. At 6 months, however, the patient developed pain, and a rapidly growing mass was detected by computed tomography. An incisional biopsy was performed. Histologic analysis showed a high-grade osteosarcoma. The patient developed lung metastases and died soon after beginning chemotherapy. The mechanism of sarcomatous transformation of GCTB during denosumab therapy is unclear. These findings suggest that the scientific community should be aware of the possible malignant transformation of GCTB during denosumab treatment. |
| Databáze: | OpenAIRE |
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