Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS

Autor: Tino Ebbers, Marcel Warntjes, Jan Engvall, Sofia Kvernby, Henrik Haraldsson, Carl-Johan Carlhäll
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
T2 mapping
Diastole
Ventricular Function
Left
Breath Holding
Nuclear magnetic resonance
Heart Rate
Predictive Value of Tests
Healthy volunteers
Heart rate
Image Interpretation
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
Medicine(all)
Observer Variation
Radiological and Ultrasound Technology
medicine.diagnostic_test
Pulse (signal processing)
business.industry
Phantoms
Imaging
Research
Myocardium
Relaxation (NMR)
Klinisk medicin
Reproducibility of Results
Magnetic resonance imaging
Relaxation time
T1 mapping
Middle Aged
Magnetic Resonance Imaging
Healthy Volunteers
medicine.anatomical_structure
Ventricle
Cardiovascular magnetic resonance
Female
Radiology
Clinical Medicine
Cardiology and Cardiovascular Medicine
business
Three-dimensional
Zdroj: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
1097-6647
Popis: BACKGROUND: Quantification of the longitudinal- and transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Methods for cardiac relaxation time mapping generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In this paper we present and evaluate a novel method for 3D interleaved T1 and T2 mapping of the whole left ventricular myocardium within a single breath hold of 15 heartbeats. METHODS: The 3D-QALAS (3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse) is based on a 3D spoiled Turbo Field Echo sequence using inversion recovery with interleaved T2 preparation. Quantification of both T1 and T2 in a volume of 13 slices with a resolution of 2.0x2.0x6.0 mm is obtained from five measurements by using simulations of the longitudinal magnetizations Mz. This acquisition scheme is repeated three times to sample k-space. The method was evaluated both in-vitro (validated against Inversion Recovery and Multi Echo) and in-vivo (validated against MOLLI and Dual Echo). RESULTS: In-vitro, a strong relation was found between 3D-QALAS and Inversion Recovery (R = 0.998; N = 10; p < 0.01) and between 3D-QALAS and Multi Echo (R = 0.996; N = 10; p < 0.01). The 3D-QALAS method showed no dependence on e.g. heart rate in the interval of 40-120 bpm. In healthy myocardium, the mean T1 value was 1083 ± 43 ms (mean ± SD) for 3D-QALAS and 1089 ± 54 ms for MOLLI, while the mean T2 value was 50.4 ± 3.6 ms 3D-QALAS and 50.3 ± 3.5 ms for Dual Echo. No significant difference in in-vivo relaxation times was found between 3D-QALAS and MOLLI (N = 10; p = 0.65) respectively 3D-QALAS and Dual Echo (N = 10; p = 0.925) for the ten healthy volunteers. CONCLUSIONS: The 3D-QALAS method has demonstrated good accuracy and intra-scan variability both in-vitro and in-vivo. It allows rapid acquisition and provides quantitative information of both T1 and T2 relaxation times in the same scan with full coverage of the left ventricle, enabling clinical application in a broader spectrum of cardiac disorders.
Databáze: OpenAIRE
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