Teasing out function from morphology: Similarities between primary cilia and immune synapses
| Autor: | Douanne, Tiphaine, Stinchcombe, Jane C, Griffiths, Gillian M |
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| Přispěvatelé: | Douanne, Tiphaine [0000-0001-8197-8358], Stinchcombe, Jane C [0000-0003-1459-9299], Griffiths, Gillian M [0000-0003-0434-5842], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Immunological Synapses
Immunology chemical and pharmacologic phenomena Biology Immunological synapse Synapse 03 medical and health sciences 0302 clinical medicine Immune system Animals Humans Cilia 030304 developmental biology 0303 health sciences Trafficking Cilium Cell Biology biochemical phenomena metabolism and nutrition CTL Centrosome Perspective Signal transduction Neuroscience 030217 neurology & neurosurgery Function (biology) Signal Transduction T-Lymphocytes Cytotoxic |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.202102089 |
| Popis: | Douanne et al. outline the multiple shared molecular mechanisms underlying two distinct biological structures, primary cilia and immune synapses. Immune synapses are formed between immune cells to facilitate communication and coordinate the immune response. The reorganization of receptors involved in recognition and signaling creates a transient area of plasma membrane specialized in signaling and polarized secretion. Studies on the formation of the immune synapse between cytotoxic T lymphocytes (CTLs) and their targets uncovered a critical role for centrosome polarization in CTL function and suggested a striking parallel between the synapse and primary cilium. Since these initial observations, a plethora of further morphological, functional, and molecular similarities have been identified between these two fascinating structures. In this review, we describe how advances in imaging and molecular techniques have revealed additional parallels as well as functionally significant differences and discuss how comparative studies continue to shed light on the molecular mechanisms underlying the functions of both the immune synapse and primary cilium. |
| Databáze: | OpenAIRE |
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