Hypothyroidism and Subclinical Hypothyroidism in the Older Patient
| Autor: | Kristin L. Kelly, Samuel L. Gurevitz, Katie L. Peterson, Jennifer A. Snyder |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
medicine.medical_specialty Pediatrics endocrine system diseases business.industry Data synthesis Thyroid Age Factors Primary hypothyroidism Levothyroxine MEDLINE medicine.anatomical_structure Endocrinology Hypothyroidism Internal medicine medicine Etiology Humans Pharmacology (medical) Clinical significance business hormones hormone substitutes and hormone antagonists Aged medicine.drug Subclinical infection |
| Zdroj: | The Consultant Pharmacist. 26:657-664 |
| ISSN: | 0888-5109 |
| DOI: | 10.4140/tcp.n.2011.657 |
| Popis: | Objective To review the etiology, precipitating factors, clinical findings, screening recommendations, and treatment for primary hypothyroidism and subclinical hypothyroidism in the older patient. Data sources A PubMed search of English language articles using a combination of words: elderly, thyroid, hypothyroid,* subclinical hypothyroid,* etiology, screening, diagnosis, and treatment to identify original studies, guidelines, and reviews on primary hypothyroidism and subclinical hypothyroidism published between 1979 and present. Study selection and data extraction Overall, 51 clinical reviews, original studies, references, and guidelines were obtained and evaluated on their clinical relevance to the older patient population. Data synthesis The literature included guidelines and considerations for the diagnosis, screening, and management of subclinical and overt primary hypothyroidism in the older patient. Conclusion Females and individuals 60 years of age or older have a higher prevalence of primary hypothyroidism and subclinical hypothyroidism. While screening recommendations exist, the need or suggested age to initiate screening varies among organizations. TSH and free T4 values are used for diagnosing and monitoring. Levothyroxine remains the drug of choice for replacing endogenous thyroid hormone. Despite evidence to suggest its need, the treatment of subclinical hypothyroidism remains controversial. |
| Databáze: | OpenAIRE |
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