Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid
| Autor: | L. D'Angelo, M. Caravaggi, G. M. Frigo, F. De Ponti, G. Guidi, Sergio Lecchini, Antonio Crema, R. Grimaldi |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Administration Oral Pharmacology Pharmacognosy High-performance liquid chromatography Drug Administration Schedule Pharmacokinetics In vivo Oral administration Drug Discovery Medicine Humans Volunteer Chromatography High Pressure Liquid Centella Plants Medicinal Traditional medicine biology Dose-Response Relationship Drug business.industry Plant Extracts biology.organism_classification Triterpenes Dose–response relationship business Pentacyclic Triterpenes |
| Zdroj: | Journal of ethnopharmacology. 28(2) |
| ISSN: | 0378-8741 |
| Popis: | A new HPLC assay method was used to investigate the pharmacokinetics of asiatic acid after oral administration of the total triterpenic fraction of Centella asiatica in single doses (30 or 60 mg) and after a 7-day treatment (30 or 60 mg twice daily). Twelve healthy volunteers received each treatment following a randomized cross-over design with trials separated by a 3-week interval. The time of peak plasma concentration was not affected by dosage difference or by treatment scheme. Differences in peak plasma concentration and area under the concentration vs. time curve from 0 to 24 h (AUC0-24) calculated after 30 or 60 mg administration (single dose) were accounted for by the different dose regimen. However, after chronic treatment with both 30 and 60 mg, peak plasma concentrations, AUC0-24 and half-life were significantly higher than those observed after the corresponding single dose administration. This phenomenon could be explained by a metabolic interaction between asiatic acid and asiaticoside, which is transformed into asiatic acid in vivo. |
| Databáze: | OpenAIRE |
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