Expression of a truncated form of hHb1 hair keratin in human breast carcinomas
| Autor: | Catherine H. Régnier, P. H. Asch, Anne Boulay, Catherine Tomasetto, M. P. Chenard, Corinne Wendling, Marlène Rio |
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| Přispěvatelé: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpital de Hautepierre [Strasbourg], univOAK, Archive ouverte |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty DNA Complementary Molecular Sequence Data Breast Neoplasms Biology Hair keratin Keratin Gene expression [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Tumor Cells Cultured Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Amino Acid Sequence Cloning Molecular Gene Aged chemistry.chemical_classification Messenger RNA Gene map Base Sequence Keratin 6A Middle Aged Blotting Northern Gene Expression Regulation Neoplastic Oncology chemistry Protein Biosynthesis Keratin 8 Cancer research Keratins Female Hair Research Article |
| Zdroj: | British Journal of Cancer British Journal of Cancer, 1998, 78 (12), pp.1640-1644. ⟨10.1038/bjc.1998.736⟩ |
| ISSN: | 0007-0920 1532-1827 |
| DOI: | 10.1038/bjc.1998.736⟩ |
| Popis: | Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthermore, an in vitro study indicated that it could be translated. We concluded that, in breast carcinomas, expression of truncated hHb1 is related to epithelial cell transformation. Because the hHb1 gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHb1 gene might represent a target for such alterations. Images Figure 2 Figure 3 Figure 4 Figure 5 |
| Databáze: | OpenAIRE |
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