New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
| Autor: | Jéssica Batista Lima, Adilva de Souza Conceição, Tania M. S. Silva, Yanna Carolina Ferreira Teles, Maria de Fátima Vanderlei de Souza, Louise Helena Guimarães de Oliveira, Diégina Araújo Fernandes, Maria Sallett R. Souza, Fabíola da Cruz Nunes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Aedes aegypti
larvicidal activity Sterculiacaeae sulphated flavonoids Pharmaceutical Science 01 natural sciences Analytical Chemistry lcsh:QD241-441 Chlorophyll derivatives Terpene chemistry.chemical_compound Helicteres lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry Larvicide Lignan Sterculiaceae biology Traditional medicine 010405 organic chemistry Velutina fungi Organic Chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Helicteres velutina Chemistry (miscellaneous) Molecular Medicine |
| Zdroj: | Molecules Volume 23 Issue 11 Molecules, Vol 23, Iss 11, p 2784 (2018) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules23112784 |
| Popis: | Helicteres velutina K. Schum (Sterculiaceae), commonly known in Brazil as &lsquo pitó &rsquo is traditionally used by indigenous peoples as insecticides and repellents. The present work reports on the the phytoconstituents from aerial parts of H. velutina and evaluation of the larvicidal potential of its extract. The compounds were isolated using chromatographic techniques and identified by NMR, IR and LC-HRMS. This study led to the isolation of a fatty acid, one aliphatic alcohol, four chlorophyll derivatives, one steroid, triterpenes, a lignan, and flavonoids, highlighting the new compounds in the literature, 5,4&prime di-hydroxy-7-methoxy-8-O-sulphate flavone (mariahine) (15a) and 5,3&prime di-hydroxy-7,4&prime dimethoxy-8-O-sulphate flavone (condadine) (15b). The work presented here contributes to the chemotaxonomic knowledge of the Sterculiaceae family by describing the occurrence of sulphated flavonoids in this family for the first time. The crude ethanolic extract of H. velutina featured robust larvicidal activity against Aedes aegypti larvae, showing that the extract can be useful as a domestic larvicide, just as indicated by traditional use, to combat A. aegypti, a vector insect of severe viral diseases, such as dengue and Zika. |
| Databáze: | OpenAIRE |
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