Diffusion Kurtosis Imaging Reflects GFAP, TopoIIα, and MGMT Expression in Astrocytomas

Autor:	Xiao-chun Wang, Yan Tan, Hui Zhang, Xiao-Yong Hao, Jiang-bo Qin, Yin Lei
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Astrocytoma Metastasis Fractional anisotropy Glial Fibrillary Acidic Protein Medicine Humans neoplasms Diffusion Kurtosis Imaging DNA Modification Methylases Glial fibrillary acidic protein biology medicine.diagnostic_test business.industry Brain Neoplasms Tumor Suppressor Proteins Ethics committee Mgmt expression Magnetic resonance imaging Proliferation activity medicine.disease DNA Repair Enzymes Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging nervous system Neurology biology.protein Neurology (clinical) business
Zdroj:	Neurology India. 69(1)
ISSN:	1998-4022
Popis:	Preliminary study of magnetic resonance (MR) diffusion kurtosis imaging (DKI) assessing the pathological glial fibrillary acidic protein (GFAP), TopoIIα, and O 6-methylguanine-DNA methyltransferase (MGMT) expression in astrocytomas.This study was approved by the local ethics committee, and informed consent was obtained from all participants. Sixty-six cases with pathologically proven astrocytomas were enrolled in this study; of which, 34 were high grade and remaining 32 were low grade. They patients underwent conventional MRI head scan, DKI scan, and enhanced scan under the same conditions. Fractional anisotropy (FA) and mean kurtosis (MK) calculated from DKI, as well as GFAP, TopoIIα, and MGMT expression level were compared prospectively between high and low-grade astrocytomas. Spearman rank correlation analysis was used for comparing values of DKI and GFAP, TopoIIα, and MGMT expression level in the two groups.The MK values were significantly higher in high-grade astrocytomas than those in low-grade astrocytomas (P0.05); FA values demonstrated no significant difference between the two groups (P = 0.331). GFAP expression level was significantly lower in high-grade astrocytomas than in low-grade astrocytomas (P0.05). Topo-IIα expression level were significantly higher in high-grade astrocytomas than in low-grade astrocytomas (P0.05). There was no significant difference in MGMT expression level between the two groups (P = 0.679). MK values were negatively correlated with the expression of GFAP (r = -0.836; P = 0.03), however, they were positively correlated with the expression of Topo-IIα (r = 0.896; P = 0.01). FA values were not correlated with the expression of GFAP (r = 0.366; P = 0.05), Topo-IIα (r = -0.562; P = 0.05), and MGMT (r = -0.153; P = 0.10).MK, the DKI parameter values of astrocytomas, was significantly correlated to the expression of GFAP and TopoIIα. To a certain extent, applying DKI may provide the biological behavior of tumor cell differentiation, proliferation activity, invasion and metastasis, and can guide individual treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e299d87f555f0b59e9fd7fa88f94fc4b https://pubmed.ncbi.nlm.nih.gov/33642282 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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