Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
| Autor: | Sean Chia, Rodrigo Cataldi, Tuomas P. J. Knowles, Christopher M. Dobson, Janet R. Kumita, Katarina Pisani, Tomas Sneideris, Priyanka Joshi, Michele Vendruscolo, Michele Perni, Sarwat Sunehera, Catherine K. Xu, Francesco Simone Ruggeri, Sara Linse, Benedetta Mannini, Johnny Habchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Amyloid beta-Peptides
Amyloid β business.industry QH301-705.5 Metabolite Dopamine Medicine (miscellaneous) Publisher Correction Chemical biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Text mining Biochemistry chemistry Alzheimer Disease Cell Line Tumor medicine Escherichia coli Humans Biology (General) General Agricultural and Biological Sciences business medicine.drug Neuroscience |
| Zdroj: | Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021) |
| ISSN: | 2399-3642 |
| Popis: | Aberrant soluble oligomers formed by the amyloid-β peptide (Aβ) are major pathogenic agents in the onset and progression of Alzheimer's disease. A variety of biomolecules can influence the formation of these oligomers in the brain, although their mechanisms of action are still largely unknown. Here, we studied the effects on Aβ aggregation of DOPAL, a reactive catecholaldehyde intermediate of dopamine metabolism. We found that DOPAL is able to stabilize Aβ oligomeric species, including dimers and trimers, that exert toxic effects on human neuroblastoma cells, in particular increasing cytosolic calcium levels and promoting the generation of reactive oxygen species. These results reveal an interplay between Aβ aggregation and key biochemical processes regulating cellular homeostasis in the brain. |
| Databáze: | OpenAIRE |
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