Osteoporosis and FRAX risk in patients with liver cirrhosis
| Autor: | Galileo Escobedo González, Azucena I. Casanova-Lara, Pilar A. Peniche-Moguel, Eduardo Pérez-Torres, Chantal Jaqueline Córdova-Gallardo, José Luis Pérez-Hernández |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Hepatic osteodystrophy FRAX Cirrhosis Bone disease Osteoporosis Chronic liver disease Gastroenterology Osteodistrofía hepática Internal medicine Bone mineral density medicine Vitamin D and neurology Osteodystrophy Densidad Mineral ósea lcsh:R5-920 Osteopenia business.industry Densitometría General Medicine medicine.disease Endocrinology lcsh:Medicine (General) business Densitometry |
| Zdroj: | Revista Médica del Hospital General de México, Vol 77, Iss 4, Pp 173-178 (2014) |
| ISSN: | 0185-1063 |
| DOI: | 10.1016/j.hgmx.2014.10.005 |
| Popis: | Background: Hepatic osteodystrophy is any bone disease in patients with chronic liver disease. To measure bone mineral density (BMD) T-score by bone densitometry (BD) is used, classifying the disease in osteopenia, osteoporosis and severe osteoporosis. There are not criteria for monitoring and detection of osteodystrophy in cases of non-cholestasic cirrhosis. To determine the risk of fracture at 10 years, Fracture Risk Assessment Tool (FRAX), could be useful. Objectives: Determine the frequency of hepatic osteodystrophy in cirrhotic patients according to BD and FRAX and identify associated risk factors. Patients and methods: An observational, analytic, cross-sectional study. We included cirrhotic patients with report of DO and FRAX. Results: 52 patients were included, 38 were female (73.1%). The mean age was 12.29 ± 55.46 year-old, MELD 4.14 ± 11.71. In cholestatic etiology Mayo Score was 2.9 ± 3.31. The BMD was 0.756 ± 0.1896 mg/ cm 2 and T-score -2.34 ± 1.0. Of all patients, 26 (50%) had ranges of osteopenia and 21 (40.4%) of osteoporosis. Fracture risk with FRAX 10-year was 7.77 ± 6,713, and when we added the value of T-score fracture risk was 13.72 ± 12. Higher prevalence of cholestatic diseases in women and viral etiology in men (P = 0.006) was observed. There was significant relationship between cholestatic etiology T-score, alkaline phosphatase, and elderly and FRAXS with T-score (P = |
| Databáze: | OpenAIRE |
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