Neutrophils instruct homeostatic and pathological states in naive tissues
| Autor: | Maria Casanova-Acebes, Magdalena Leiva, Juan A. Quintana, José Ángel Nicolás-Ávila, Sapna Devi, Héctor Peinado, José M. Adrover, Andrés Hidalgo, Georgiana Crainiciuc, Noelia A-Gonzalez, Lai Guan Ng, Susana García-Silva, Arthur Mortha, Jackson LiangYao Li, Matthias Gunzer, Miriam Merad, Oliver Soehnlein, Takashi Nagasawa, Kyle Burrows, Akhila Balachander, Iván Ballesteros, Christian Weber, Linnea A. Weiss, Andrea Rubio-Ponce |
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| Přispěvatelé: | Deutsche Forschungsgemeinschaft (Alemania), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid (España), Canadian Institutes of Health Research, Fundación ProCNIC, Biochemie, RS: CARIM - R3.07 - Structure-function analysis of the chemokine interactome for therapeutic targeting and imaging in atherosclerosis |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Lung Neoplasms Transcription Genetic P-selectin Neutrophils Phagocytosis ROR-GAMMA-T BONE-MARROW Immunology Medizin Biology GRANULOCYTES medicine.disease_cause Interleukin-23 Article PHAGOCYTOSIS Mice 03 medical and health sciences RAR-related orphan receptor gamma FLUORESCENT PROTEIN Granulocyte Colony-Stimulating Factor medicine Animals Immunology and Allergy Neoplasm Invasiveness HEMATOPOIETIC STEM-CELLS HETEROGENEITY MACROPHAGES Lung Melanoma Research Articles Mice Knockout P-SELECTIN medicine.disease 3. Good health Cell biology 030104 developmental biology medicine.anatomical_structure MAINTENANCE Neutrophil Infiltration Female Bone marrow Carcinogenesis Infiltration (medical) Homeostasis |
| Zdroj: | The Journal of Experimental Medicine Journal of Experimental Medicine Repisalud Instituto de Salud Carlos III (ISCIII) Journal of Experimental Medicine, 215(11), 2778-2795. Rockefeller University Press |
| ISSN: | 0022-1007 |
| Popis: | Neutrophils enter tissues to mediate immunity and inflammation. Casanova-Acebes et al. show that migration into naive tissues is equally important. In the intestine, they provide remote support to hematopoietic niches, whereas in the lungs they regulate circadian transcription and metastasis. Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of Il23 transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states. Graphical Abstract |
| Databáze: | OpenAIRE |
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