Enantioselective Access to 1H -Isoindoles with Quaternary Stereogenic Centers by Palladium(0)-Catalyzed C−H Functionalization

Autor:	Daria S. Grosheva, Nicolai Cramer
Rok vydání:	2018
Předmět:	Steric effects Isoindoles 010405 organic chemistry Enantioselective synthesis chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Stereocenter chemistry Nucleophile Electrophile Palladium
Zdroj:	Angewandte Chemie International Edition. 57:13644-13647
ISSN:	1433-7851
DOI:	10.1002/anie.201809173
Popis:	A catalytic enantioselective method for the synthesis of chiral 1H-isoindoles bearing quaternary stereogenic centers is reported. Powered by readily accessible phosphordiamidite ligands, the presented palladium(0)-catalyzed C-H functionalization uses trifluoroacetimidoyl chlorides as electrophilic components. It delivers previously inaccessible perfluoroalkylated 1H-isoindoles in high yields and enantioselectivities. The subsequent diastereoselective addition of nucleophiles provides access to densely substituted and sterically hindered isoindolines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29670d92e62245d4d33dbb5f68e014a https://doi.org/10.1002/anie.201809173 Zobrazit plný text záznamu Plný text