Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus

Autor: Carlos López Menéndez, Ana María García Vicente, José María Borrás Moreno, José Manuel Cordero García, Ángel Soriano Castrejón
Rok vydání: 2020
Předmět:
Zdroj: Clinical Nuclear Medicine. 45:394-397
ISSN: 1536-0229
0363-9762
DOI: 10.1097/rlu.0000000000003006
Popis: Gliomas are characterized by intratumoral histological heterogeneity, coexisting foci of low and high grade. First, in low-grade gliomas, neoangiogenesis has not yet developed and cellularity is low, so alterations on perfusion MRI may not be present. Second, a non-negligible number of high-grade gliomas show none, patchy, or weak contrast enhancement on MRI, so they can be misdiagnosed as low-grade glioma, preventing their correct management. We present 4 cases of patients in which F-fluorocholine PET defined the anaplastic tumor component and therefore the tumor aggressiveness, solving the limitations of MRI.
Databáze: OpenAIRE