Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus
Autor: | Carlos López Menéndez, Ana María García Vicente, José María Borrás Moreno, José Manuel Cordero García, Ángel Soriano Castrejón |
---|---|
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Focus (geometry) Choline 030218 nuclear medicine & medical imaging Neovascularization 03 medical and health sciences 0302 clinical medicine Glioma medicine Humans Radiology Nuclear Medicine and imaging High-Grade Glioma Neoplasm Grading Neovascularization Pathologic medicine.diagnostic_test Brain Neoplasms business.industry Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Radiology medicine.symptom business 18F-fluorocholine |
Zdroj: | Clinical Nuclear Medicine. 45:394-397 |
ISSN: | 1536-0229 0363-9762 |
DOI: | 10.1097/rlu.0000000000003006 |
Popis: | Gliomas are characterized by intratumoral histological heterogeneity, coexisting foci of low and high grade. First, in low-grade gliomas, neoangiogenesis has not yet developed and cellularity is low, so alterations on perfusion MRI may not be present. Second, a non-negligible number of high-grade gliomas show none, patchy, or weak contrast enhancement on MRI, so they can be misdiagnosed as low-grade glioma, preventing their correct management. We present 4 cases of patients in which F-fluorocholine PET defined the anaplastic tumor component and therefore the tumor aggressiveness, solving the limitations of MRI. |
Databáze: | OpenAIRE |
Externí odkaz: |