Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine)
| Autor: | Arnold Brossi, Anjum Muzaffar, Ernest Hamel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
Deacetylcolchicine Colchicum Plants Medicinal Molecular Structure Stereochemistry Polymers Organic Chemistry Pharmaceutical Science Biology biology.organism_classification In vitro Analytical Chemistry chemistry.chemical_compound Alkaloids Complementary and alternative medicine chemistry Tubulin Drug Discovery Molecular Medicine Tubulin polymerization Colchicine |
| Zdroj: | Journal of natural products. 53(4) |
| ISSN: | 0163-3864 |
| Popis: | Two minor Colchicum alkaloids, N-acetoacetyl-deacetylcolchicine [1] and 2-demethylspeciosine [7], were synthesized. The diacetate 8 of 2-demethylspeciosine was also prepared. The antitubulin activity of these compounds, in comparison to colchicine, was measured. N-Acetoacetyl-deacetylcolchicine [1] has in vitro activity similar to that of colchicine. Both 2-demethylspeciosine [7] and the diacetate 8 were considerably less potent inhibitors of tubulin polymerization. |
| Databáze: | OpenAIRE |
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