Topical ER36009, a RARγ-Selective Retinoid, Decreases Abdominal White Adipose Tissue and Elicits Changes in Expression of Genes Related to Adiposity and Thermogenesis
Autor: | Toshiji Kanayama, Taro Uchiyama, Tomohiro Sakuta |
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Rok vydání: | 2006 |
Předmět: |
Male
medicine.medical_specialty Adipose Tissue White Endocrinology Diabetes and Metabolism Adipose tissue macrophages Adipose tissue Peroxisome proliferator-activated receptor White adipose tissue Ion Channels Mitochondrial Proteins Rats Sprague-Dawley Eating Endocrinology Adipose Tissue Brown Quinoxalines Internal medicine Brown adipose tissue medicine Animals Uncoupling Protein 3 RNA Messenger Uncoupling Protein 1 Adiposity bcl-2-Associated X Protein PRDM16 chemistry.chemical_classification Reverse Transcriptase Polymerase Chain Reaction Body Weight Thermogenesis Blotting Northern Thermogenin Rats Up-Regulation PPAR gamma Thiazoles medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 chemistry 11-beta-Hydroxysteroid Dehydrogenases |
Zdroj: | Endocrine. 30:113-120 |
ISSN: | 0969-711X |
DOI: | 10.1385/endo:30:1:113 |
Popis: | Chronic topical treatment of rats with a new RARgamma-selective retinoid, ER36009, resulted in a significant reduction of epididymal white adipose tissue and a significant increase of interscapular brown adipose tissue without affecting food intake. ER36009 markedly decreased PPARgamma, 11beta-HSD1, and Bcl-2 mRNA levels, and increased Bax mRNA in white adipose tissue, while it upregulated UCP1 and UCP3 mRNAs in brown adipose tissue and UCP3 mRNA in gastrocnemial muscle. These results suggest that ER36009 has multiple effects on adipose tissue biology and the energy balance. Topically applied ER36009 may have potential for the treatment of obesity. |
Databáze: | OpenAIRE |
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