Inflammatory agents involved in septic miscarriage
| Autor: | Julieta Aisemberg, Silvia Billi, Ana Maria Franchi, Claudia Alejandra Vercelli, Manuel Luis Wolfson, Mariana Farina, Ana Inés Salazar, María Laura Ribeiro, Claudia Osycka-Salut |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Early Pregnancy Loss Immunology Abortion Septic Nitric Oxide Miscarriage Sepsis Mice Endocrinology Pregnancy Cannabinoid Receptor Modulators medicine Animals Humans reproductive and urinary physiology Nitrites Inflammation Endocrine and Autonomic Systems business.industry Obstetrics medicine.disease Embryo Mammalian Abortion Spontaneous Disease Models Animal Neurology embryonic structures Prostaglandins Female Inflammation Mediators business |
| Zdroj: | Neuroimmunomodulation. 17(3) |
| ISSN: | 1423-0216 |
| Popis: | Even though the understanding of the cause of early pregnancy loss due to chromosomal abnormalities has improved, there is a dearth of knowledge of the causes of loss in euploid conceptuses. Maternal infections are a cause of abort in humans, but the mechanisms are not clear, so we have developed a murine model to study the mechanism of septic abortion by inducing embryonic resorption (ER) with lipopolysaccharide (LPS). We demonstrated that augmented production of nitric oxide (NO) and prostaglandins (PG) is involved in ER, and that inhibitors of their synthesis could prevent ER. Also, we observed an increase in the oxidative damage, evidenced by nitration of tyrosine proteins, due to the peroxynitrite anion. Since an association between chronic marijuana smoking and early miscarriage has been shown in women, we studied the participation of anandamide (AEA), the principal endocannabinoid, on the mechanism of action of LPS. We showed that LPS-induced NO synthesis and tissue damage were mediated by AEA, and that this endotoxin inhibited AEA degradation and increased its synthesis. These results suggest that several inflammatory molecules participate in the mechanism of early pregnancy loss and that their modulation could be useful tools to prevent it. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|