Apoptotic signaling in salivary mucoepidermoid carcinoma
| Autor: | Renata Carolina Fraga Ianez, Cláudia Malheiros Coutinho-Camillo, Elen Alves de Sousa, Gabriela M da Silva, Maria Aparecida Nagai, Ágatha Nagli de Mello Gomes, Natalie Kelner, Silvia Vanessa Lourenço, Victoria Saavedra, Luiz Paulo Kowalski, Fernando Augusto Soares |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Organogenesis Apoptosis Fas ligand 03 medical and health sciences 0302 clinical medicine Mucoepidermoid carcinoma Survivin Biomarkers Tumor Medicine Humans fas Receptor Pathological MUC1 business.industry Caspase 3 Mucin-1 medicine.disease Prognosis Salivary Gland Neoplasms Immunohistochemistry stomatognathic diseases 030104 developmental biology Ki-67 Antigen Otorhinolaryngology 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer research Carcinoma Mucoepidermoid Female business Apoptosis Regulatory Proteins Transcription Factors |
| Zdroj: | Headneck. 41(9) |
| ISSN: | 1097-0347 |
| Popis: | Background Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. Methods The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. Results Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. Conclusions The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text