Topical application of tranexamic acid after adenoidectomy: A double-blind, prospective, randomized, controlled study
| Autor: | Ahmed A Eldaba, Ahmed Sobhy Basuni, Emad M. Shehata, Magdy E. Saafan, Osama A. Albirmawy |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Blood transfusion Adolescent medicine.medical_treatment Postoperative Hemorrhage law.invention Adenoidectomy Double-Blind Method Randomized controlled trial law Humans Medicine Prospective Studies Child Prospective cohort study Saline business.industry Infant General Medicine Antifibrinolytic Agents Hemostasis Surgical Surgery Treatment Outcome Tranexamic Acid Otorhinolaryngology Child Preschool Anesthesia Hemostasis Pediatrics Perinatology and Child Health Female business Tranexamic acid medicine.drug |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 77:1139-1142 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2013.04.021 |
| Popis: | Objective Is to evaluate the efficacy of tranexamic acid when applied locally in children after primary isolated adenoidectomy with respect to intra-operative blood loss and post-operative bleeding. Study design Prospective, double-blind, randomized, controlled trial. Setting Otolaryngology department, Tanta University and Tiba Hospitals, Egypt. Patients and methods Over three years, 400 children underwent primary isolated adenoidectomy followed by topical application of tranexamic acid (tranexamic acid group, 200 children) or saline (Placebo group, 200 children) with at least two weeks’ follow up. Intra-operative blood loss and post-operative hemorrhage were monitored. Results Both groups were almost equivalent in age and gender. The frequency of primary post-adenoidectomy hemorrhage as well as the rate of postnasal packing and blood transfusion required to manage severe bleeding were higher in placebo group. The volume of blood loss during surgery showed significant reduction in tranexamic acid group. Conclusion Topical application of tranexamic acid after adenoidectomy led to a significant reduction in blood loss during surgery and decreasing in the rate of post-operative bleeding as well as the need for postnasal packing and blood transfusion. |
| Databáze: | OpenAIRE |
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