Efect of dual growth factor administration on oxidative markers during acute stage wound healing in rats
| Autor: | Şule Coşkun Cevher, Bahar Dindar, Kaan Kaltalioğlu |
|---|---|
| Přispěvatelé: | Meslek Yüksekokulları, Espiye Meslek Yüksekokulu, Mülkiyet Koruma ve Güvenlik Bölümü, Kaltalioğlu, Kaan |
| Rok vydání: | 2017 |
| Předmět: |
040301 veterinary sciences
medicine.medical_treatment VEGF receptors 030232 urology & nephrology Oxidative phosphorylation Pharmacology medicine.disease_cause 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine Wound Healing biology business.industry Growth factor 04 agricultural and veterinary sciences PDGF VEGF Acute stage Oxidative Stress Wound healing oxidative stress PDGF VEGF biology.protein Animal Science and Zoology Wound healing business Oxidative stress Platelet-derived growth factor receptor |
| Zdroj: | Volume: 41, Issue: 5 841-847 Turkish Journal of Zoology |
| ISSN: | 1300-0179 1303-6114 |
| Popis: | WOS: 000412127600008 \Wound healing is a complex process affected by various conditions, including oxidative stress. The present study explored the time-dependent effects of platelet-derived growth factor (PGDF) and vascular endothelial growth factor (VEGF) administration on oxidative markers during acute stage wound healing. Thirty-six Wistar rats were distributed into three major groups; skin wounds were inflicted in all groups. The wounds were either left untreated (control group), treated topically with blank chitosan gel (blank chitosan gel group), or treated topically with a combination of PDGF and VEGF in chitosan gel (PDGF + VEGF chitosan gel group). Wounds were sampled on postsurgery days 3 and 7; samples were assayed for the oxidant markers nitric oxide (NOx) and thiobarbituric acidreactive substances (TBARs) and the antioxidant markers glutathione (GSH), ascorbic acid (AA), and superoxide dismutase (SOD) activity. PDGF + VEGF administration increased and decreased NOx levels on days 3 and 7, respectively. PDGF + VEGF administration lowered TBARs levels, compared with blank chitosan gel administration, on day 7. PDGF + VEGF administration increased GSH levels. These results demonstrate that PDGF + VEGF administration changes oxidative status of wound tissue. This study provides valuable insights for the development of therapeutic targets that promote wound healing. |
| Databáze: | OpenAIRE |
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