In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
| Autor: | Jennifer A. Mitchel, M. Angela Nieto, Stephan A. Koehler, Michael O'Sullivan, Dapeng Bi, Ian T. Stancil, James P. Butler, Jeffrey J. Fredberg, Stephen J. DeCamp, Oscar H. Ocaña, Amit Das, Jin-Ah Park |
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| Přispěvatelé: | Northeastern University (US), American Heart Association, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition Science Cell Plasticity Primary Cell Culture General Physics and Astronomy Cancer metastasis Collective cell migration Bronchi Respiratory Mucosa General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Cell Movement Humans Regeneration Epithelial–mesenchymal transition lcsh:Science Barrier function Cells Cultured Multidisciplinary Transition (genetics) Chemistry Regeneration (biology) Mesenchymal stem cell digestive oral and skin physiology Cell migration Epithelial Cells General Chemistry Cell biology 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Cellular motility embryonic structures lcsh:Q Biological physics |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature Communications Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2041-1723 |
| Popis: | The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration. The authors acknowledge the support of the Northeastern University Discovery Cluster and TIER 1 Seed Grant for interdisciplinary research, P01HL120839, R01HL148152, U01CA202123, T32HL007118, P30DK065988, the Parker B. Francis Foundation, American Heart Association (13SDG 14320004), the Spanish Ministry of Science, Research, and Innovation (RTI2018-096501-B-I00). |
| Databáze: | OpenAIRE |
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