The Iron State in Spleen and Liver Tissues from Patients with Hematological Malignancies Studied Using Magnetization Measurements and Mössbauer Spectroscopy
| Autor: | A. V. Vinogradov, T. S. Konstantinova, M. I. Oshtrakh, I. V. Alenkina, Erno Kuzmann, Vladimir A. Semionkin, Israel Felner |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lymphoma B-Cell Iron Biophysics Spleen Biochemistry 03 medical and health sciences Magnetization Magnetics Spectroscopy Mossbauer Nuclear magnetic resonance Mössbauer spectroscopy medicine Humans Myelofibrosis Microscopy 030102 biochemistry & molecular biology Chemistry Temperature Myeloid leukemia Cell Biology General Medicine medicine.disease Marginal zone Lymphoma Leukemia Myeloid Acute 030104 developmental biology medicine.anatomical_structure Liver Primary Myelofibrosis Hematologic Neoplasms Ferritins Mantle cell lymphoma |
| Zdroj: | Cell biochemistry and biophysics. 77(1) |
| ISSN: | 1559-0283 |
| Popis: | In this overview, we present the results of the study of spleen and liver tissues taken from healthy donors in comparison with those from patients with (i) non-Hodgkin B-cell lymphomas, namely, mantle cell lymphoma and marginal zone B-cell lymphoma, (ii) acute myeloid leukemia, and (iii) primary myelofibrosis. The study was carried out using Mossbauer spectroscopy and magnetization measurements for the analysis of ferritin-like iron in spleen and liver tissues. Magnetization measurements demonstrated small differences in the saturation magnetic moments and revealed additional paramagnetic components. Two liver samples demonstrated unusual behavior of the magnetic moment when the zero-field-cooled curve was over the field-cooled curve in the temperature range between ~40 and ~70 K. Relative iron content variations in the tissue cells as well as small variations in the 57Fe hyperfine parameters were demonstrated for healthy and patients’ spleen and liver tissues on the base of measured Mossbauer spectra. The results obtained permit us to suggest small differences in the ferritin iron core structure in spleen and liver tissues from healthy donors and patients with hematological malignancies. |
| Databáze: | OpenAIRE |
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