Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving non-myeloablative conditioning and a haploidentical related allogeneic bone marrow transplant
| Autor: | Christine Colby, Han Chong Toh, Frederic I. Preffer, Robert Sackstein, Thomas R. Spitzer, Jeffrey S. Clark, Megan Sykes, Susan L. Saidman, David Dombkowski, Steve McAfee, Stephen Alexander |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Time Factors Transplantation Conditioning Lymphoma Recombinant Fusion Proteins Lymphocyte medicine.medical_treatment Immunology chemical and pharmacologic phenomena Immune tolerance Immune system immune system diseases hemic and lymphatic diseases medicine Humans Transplantation Homologous Immunology and Allergy Lymphocytes Bone Marrow Transplantation Pharmacology Clinical Trials as Topic business.industry Immunotherapy Middle Aged Flow Cytometry Mixed lymphocyte reaction Donor Lymphocytes medicine.disease Lymphocyte Subsets Kinetics surgical procedures operative medicine.anatomical_structure Bone marrow business |
| Zdroj: | Cytokines, Cellular & Molecular Therapy. 7:43-47 |
| ISSN: | 1368-4736 |
| DOI: | 10.1080/13684730412331302054 |
| Popis: | A 51-year-old patient with refractory non-Hodgkin lymphoma (NHL) received non-myeloablative conditioning and a two of six (A, B, DR) human leucocyte antigen (HLA) mismatched donor BMT. Post-BMT lymphocytes showed fluctuating T- and natural killer (NK)-cell chimerism, which culminated in mainly donor lymphocytes by Day + 100. Changes in lymphocyte chimerism correlated with anti-donor and anti-host responses in mixed lymphocyte reaction (MLR). On Day + 100, a strong anti-host response was observed in MLR in the absence of graft-versus-host disease (GVHD), together with near complete regression of the patient's lymphoma. A mild chronic GVHD later developed and, eventually, by 680 days post-BMT, the lymphoma had relapsed and MLR reflected a state of global immune unresponsiveness. These observations demonstrate evolving host-versus-graft and graft-versus-host tolerance that correlates with fluctuating lymphoid chimerism and graft-versus-lymphoma (GVL) effects, in the absence of severe GVHD. Eventual lymphoma relapse temporally correlated with a generalised immunosuppressed state. |
| Databáze: | OpenAIRE |
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