Single-Agent versus Combination Doxorubicin-Based Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Single-Blind, Randomized, Phase II Trial
| Autor: | Xu He, Yong Li, You-bing Zheng, Jian-Wen Huang, Bao-shan Hu, Ligong Lu, Bing Liu, Wei Zhao |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty China Carcinoma Hepatocellular Mitomycin Urology Antineoplastic Agents Kaplan-Meier Estimate Deoxycytidine Disease-Free Survival law.invention Hepatic Artery Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Single agent Doxorubicin Neoplasm Invasiveness Single-Blind Method Chemoembolization Therapeutic Aged Neoplasm Staging business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Prognosis Gemcitabine Clinical trial Treatment Outcome Oncology Hepatocellular carcinoma Lymphatic Metastasis Female Single blind business Tomography X-Ray Computed medicine.drug Follow-Up Studies |
| Zdroj: | Oncology. 89(1) |
| ISSN: | 1423-0232 |
| Popis: | Objectives: It was the aim of this study to find an optimal therapeutic regimen of transarterial chemoembolization (TACE) by comparing the efficacy of chemoembolization with different anticancer agents in hepatocellular carcinoma (HCC) patients. Methods: A single-blind, three-group parallel, randomized trial was conducted in Guangdong General Hospital, Guangzhou, China, with patients with biopsy-confirmed HCC. Group 1 received single-drug (doxorubicin) chemoembolization, while group 2 received double-drug (doxorubicin and mitomycin C) chemoembolization. Patients in group 3 were treated with triple-drug (doxorubicin, mitomycin C, and gemcitabine) chemoembolization. Lipiodol was used as embolization agent in all protocols. We compared the overall survival (OS), time to progression (TTP), and objective response rate (ORR) between groups. Response assessment was performed according to modified RECIST (Response Evaluation Criteria In Solid Tumors) criteria. Results: Between January 2008 and January 2011, 162 patients (group 1, n = 50; group 2, n = 59; group 3, n = 53) were recruited. The OS and TTP in groups 1, 2, and 3 were 14.9 and 6.4, 13.2 and 6.4, and 20.5 and 6.8 months, respectively. OS and TTP were statistically significant among groups (p = 0.002 and p = 0.037). The ORR was 22.0, 40.7, and 56.6%, respectively. The ORR was significantly different across the three groups (p < 0.002). Conclusions: TACE with multiple chemotherapeutic agents might significantly increase survival and tumor response; additionally, gemcitabine was likely to have an advantage in improving the prognosis of HCC patients. |
| Databáze: | OpenAIRE |
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