Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis

Autor:	Yi-Fan Yu, Chun-Xue Yu, Ye Zhao, Dong-Qing Fei, Zhan-Xin Zhang, Pei-Qian Wu, Feng-Ming Qi, Zhi Dejuan
Rok vydání:	2018
Předmět:	Disease activity 010404 medicinal & biomolecular chemistry Anti alzheimer 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Nardostachys chinensis Physical and Theoretical Chemistry 01 natural sciences Biochemistry Structural framework 0104 chemical sciences
Zdroj:	Organic & Biomolecular Chemistry. 16:9038-9045
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c8ob02319k
Popis:	Nardochinins A-D (1-4), four novel sesquiterpenoids, along with four known ones were isolated from the underground parts of Nardostachys chinensis Batal in ethanol. Their structures were determined by extensive spectroscopic methods and single-crystal X-ray diffraction. Nardochinin A (1) possessed a norsesquiterpene skeleton with an unusual 3/6/5/5 tetracyclic ring system, which had not appeared in natural products. Nardochinins B (2) and C (3) were the first time found naturally occurring sesquiterpenoids with a 4,5-seco-nardosinane skeleton. Besides, compound 3 represented an unprecedented 4,5-seco-nardosinane type norsesquiterpenoid with losing an isopropenyl at C-6 compared with 2 in the structural framework. Nardochinin D (4) was a novel, highly oxygenated valerenane-type sesquiterpenoid possessing a rare 3,12-epoxy group and an unusual 9,11-epoxy group. The anti-Alzheimer's disease (AD) activities of 1-4 were also evaluated using the Caenorhabditis elegans AD pathological model, and nardochinin B (2) had the highest anti-AD activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28603753a9148de9e202d0fb64bc1ce https://doi.org/10.1039/c8ob02319k Zobrazit plný text záznamu