The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

Autor:	Alicia S Borggreve, Robin B den Boer, Gijs I van Boxel, Jelle P. Ruurda, Wouter B. Veldhuis, Elles Steenhagen, Pim A. de Jong, Richard van Hillegersberg
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Review sarcopenia 03 medical and health sciences 0302 clinical medicine medicine risk factors 030212 general & internal medicine business.industry gastric cancer Hazard ratio ct scan lcsh:R Cancer General Medicine Odds ratio medicine.disease Confidence interval gastrectomy muscle mass 030220 oncology & carcinogenesis Sarcopenia Meta-analysis Gastrectomy Radiology Risk assessment business prognostication
Zdroj:	Journal of Clinical Medicine, Vol 9, Iss 1, p 199 (2020) Journal of Clinical Medicine
ISSN:	2077-0383
Popis:	Risk assessment is relevant to predict outcomes in patients with gastric cancer. This systematic review aimed to investigate the predictive value of low muscle mass for postoperative complications in gastric cancer patients. A systematic literature search was performed to identify all articles reporting on muscle mass as measured on computed tomography (CT) scans in patients with gastric cancer. After full text screening, 15 articles reporting on 4887 patients were included. Meta-analysis demonstrated that patients with low muscle mass had significantly higher odds of postoperative complications (odds ratio (OR): 2.09, 95% confidence interval (CI): 1.55−2.83) and severe postoperative complications (Clavien−Dindo grade ≥III, OR: 1.73, 95% CI: 1.14−2.63). Moreover, patients with low muscle mass had a significantly higher overall mortality (hazard ratio (HR): 1.81, 95% CI: 1.52−2.14) and disease-specific mortality (HR: 1.58, 95% CI: 1.36−1.84). In conclusion, assessment of muscle mass on CT scans is a potential relevant clinical tool for risk prediction in gastric cancer patients. Considering the heterogeneity in definitions applied for low muscle mass on CT scans in the included studies, a universal cutoff value of CT-based low muscle mass is required for more reliable conclusions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2858747ad40c8f2a1a3bd9a34e65c26 https://www.mdpi.com/2077-0383/9/1/199 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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