Glutamatergic and GABA-ergic abnormalities in First-episode depression. A 1-year follow-up 1H-MR spectroscopic study
| Autor: | Muriel Vicent-Gil, Dolors Puigdemont, Metodi Draganov, Yolanda Vives-Gilabert, Javier de Diego-Adeliño, Maria J. Portella |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Glutamine Proton Magnetic Resonance Spectroscopy Ventromedial prefrontal cortex Glutamic Acid Prefrontal Cortex 03 medical and health sciences Glutamatergic GABA 0302 clinical medicine Internal medicine medicine Humans Proton magnetic spectroscopy First- episode depression gamma-Aminobutyric Acid Depression (differential diagnoses) First episode Depressive Disorder Major Depression business.industry Glutamate receptor Repeated measures design medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Endocrinology medicine.anatomical_structure Major depressive disorder GABAergic Glutamate business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | JOURNAL OF AFFECTIVE DISORDERS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0165-0327 |
| Popis: | Background: Previous magnetic resonance spectroscopic (MRS) studies have reported brain metabolic abnormalities in Major Depressive Disorder (MDD). Nevertheless, results have been inconsistent, focusing on fully developed major depression neglecting first episode patients (FED). Longitudinal studies have also been rare and with short follow-up periods. The aim of the current study was to investigate the differences between healthy controls and first episode patients at baseline, together with changes of metabolites after 1 year follow-up in the ventromedial prefrontal cortex. Methods: H-1-MRS images were obtained from 64 healthy controls and 31 FED patients using a 3T Philips Achieva scanner and processed with TARQUIN software at baseline and after 1 year. Examined metabolites included Glx (corresponding to Glu + Gln-peak), Glu, NAAG, myo-Ins, Cr, GSH and GABA. Clinical improvement was assessed by HDRS-17 scale. Differences in the concentrations of metabolites were evaluated by MANOVA/MANCOVA and GLM repeated measures for longitudinal changes. Results: FED patients had significantly decreased glutamate levels at baseline (p < 0.05) along with significantly elevated GABA (p < 0.01) compared to healthy controls. At the follow up, myo- Ins levels were significantly increased compared to baseline (p < 0.05). Limitations: The limited sample size, together with the unexpectedly high response rate after treatment (83%) might suggest decreased representativeness of the sample. Conclusions: Results indicate glutamatergic and GABAergic changes taking place within the ventromedial prefrontal region even at the early stage of depression prior to any medication treatment. |
| Databáze: | OpenAIRE |
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