Expression of CD90 and P75NTR stem cell markers in ameloblastomas: a possible role in their biological behavior
| Autor: | Eliete Neves Silva Guerra, Sérgio Elias Vieira Cury, Carolinne Almeida Coelho, Andrielle Dias, Brunno Santos de Freitas Silva, Fernanda Paula Yamamoto Silva, Ana Elizia Mascarenhas Marques, Andrea Mantesso, Daniel de Almeida Decurcio |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stromal cell Adolescent Angiogenesis Nerve Tissue Proteins Stem cells Receptors Nerve Growth Factor Biology Stem cell marker Statistics Nonparametric Ameloblastoma 03 medical and health sciences Young Adult 0302 clinical medicine medicine Biomarkers Tumor Humans General Materials Science CD90 Antigens Thy-1 Paraffin Embedding Endothelial Cells Antígenos 030206 dentistry Fibroblasts Middle Aged medicine.disease Immunohistochemistry lcsh:RK1-715 Mandibular Neoplasms 030220 oncology & carcinogenesis lcsh:Dentistry Neoplastic Stem Cells Thy-1 Antigens Female Stem cell Stromal Cells Células-tronco Immunostaining |
| Zdroj: | Brazilian Oral Research, Volume: 30, Issue: 1, Article number: e109, Published: 10 OCT 2016 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Brazilian Oral Research, Vol 30, Iss 1 Brazilian Oral Research v.30 n.1 2016 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| ISSN: | 1807-3107 |
| Popis: | Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively. The Kolmogorov-Smirnov test was used to verify possible differences in CD90 and P75NTR expressions between multicystic and unicystic ameloblastomas (p < 0.05). CD90 immunostaining was observed in all multicystic ameloblastoma specimens (n = 10), in the cytoplasm of the fibroblasts and vascular endothelial cells of the tumor stroma, near the neoplastic odontogenic epithelia. The staining of stromal CD90 was significantly higher in multicystic than in unicystic ameloblastomas (p = 0.003). Nuclear P75NTR immunostaining was observed in all ameloblastoma specimens. A significant difference was seen in the epithelial staining of P75NTR between multicystic and unicystic types (p = 0.007). The increased expression of CD90 and P75NTR found in multicystic ameloblastomas suggests a behavioral biological difference between multicystic and unicystic ameloblastomas, as well as a difference in ameloblastoma development. |
| Databáze: | OpenAIRE |
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