Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics
| Autor: | Juan Carlos Rodriguez-Diaz, Carlos Sainz-Urruela, Alberto Falco, Stuart I. Jenkins, Amalia Mira, Ricardo Mallavia, Helena Codina |
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| Přispěvatelé: | Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDIBE), Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche |
| Rok vydání: | 2020 |
| Předmět: |
PMVE
General Chemical Engineering Chemical structure Nanoparticle 02 engineering and technology Q1 030226 pharmacology & pharmacy antibiotics RS nanoencapsulation Nanomaterials lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine nanofibers pmve/ma MA General Materials Science polymers electrospinning chemistry.chemical_classification Communication Polymer PMVE/MA 021001 nanoscience & nanotechnology R1 Combinatorial chemistry Electrospinning Solvent lcsh:QD1-999 chemistry Nanofiber Drug delivery nanoparticles 0210 nano-technology RA biomaterials |
| Zdroj: | REDIUMH: Depósito Digital de la UMH Universidad Miguel Hernández de Elche Nanomaterials r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname Nanomaterials, Vol 10, Iss 3, p 486 (2020) REDIUMH. Depósito Digital de la UMH Universidad Pontificia Comillas ICAI-ICADE |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano10030486 |
| Popis: | Recent advances in the field of nanotechnology such as nanoencapsulation offer new biomedical applications, potentially increasing the scope and efficacy of therapeutic drug delivery. In addition, the discovery and development of novel biocompatible polymers increases the versatility of these encapsulating nanostructures, enabling chemical properties of the cargo and vehicle to be adapted to specific physiological requirements. Here, we evaluate the capacity of various polymeric nanostructures to encapsulate various antibiotics of different classes, with differing chemical structure. Polymers were sourced from two separate derivatives of poly(methyl vinyl ether-alt-maleic anhydride) (PMVE/MA): an acid (PMVE/MA-Ac) and a monoethyl ester (PMVE/MA-Es). Nanoencapsulation of antibiotics was attempted through electrospinning, and nanoparticle synthesis through solvent displacement, for both polymers. Solvent incompatibilities prevented the nanoencapsulation of amikacin, neomycin and ciprofloxacin in PMVE/MA-Es nanofibers. However, all compounds were successfully loaded into PMVE/MA-Es nanoparticles. Encapsulation efficiencies in nanofibers reached approximately 100% in all compatible systems; however, efficiencies varied substantially in nanoparticles systems, depending on the tested compound (14%–69%). Finally, it was confirmed that both these encapsulation processes did not alter the antimicrobial activity of any tested antibiotic against Staphylococcus aureus and Escherichia coli, supporting the viability of these approaches for nanoscale delivery of antibiotics This research was funded by the Spanish Ministerio de Economía y Competitividad, grant numbers MAT-2017-86805-R and MAT-2014-53282-R, and Spanish Ministerio de Ciencia e Innovación (MCI)—Agencia Estatal de Investigación (AEI)/Fondo Europeo de Desarrollo Regional (FEDER), grant number RTI2018-101969-J-I00 |
| Databáze: | OpenAIRE |
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