Liver stiffness measured by transient elastography correlates with fibrosis area in liver biopsy in patients with chronic hepatitis C
| Autor: | Masao Harata, Takuji Nakano, Kyoko Kobayashi, Yuko Arima, Senju Hashimoto, Naohiro Ichino, Hiroaki Shimazaki, Hiroko Sugiyama, Yoko Hosoe, Michihito Murao, Keisuke Osakabe, Hisako Aoki, Toru Nishikawa, Naoto Kawabe, Yoshifumi Nitta, Naruomi Komura, Kentaro Yoshioka |
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| Rok vydání: | 2009 |
| Předmět: |
Prothrombin time
medicine.medical_specialty Cirrhosis Hepatology biology medicine.diagnostic_test business.industry Hepatitis C medicine.disease Gastroenterology Infectious Diseases Fibrosis Internal medicine Liver biopsy medicine biology.protein Liver function Gamma-glutamyltransferase Transient elastography business |
| Zdroj: | Hepatology Research. 39:675-684 |
| ISSN: | 1872-034X 1386-6346 |
| DOI: | 10.1111/j.1872-034x.2009.00500.x |
| Popis: | Liver stiffness (LS) measured by transient elastography (TE) has been reported to correlate with liver fibrosis, which is usually semiquantitatively assessed. In the present study, the fibrosis area was measured by image analysis software in liver biopsy specimens and its correlation with LS was assessed.LS was measured by TE in all 165 patients with chronic hepatitis C virus (HCV) infection who underwent liver biopsy consecutively in Fujita Health University Hospital from July 2004 to September 2007.Fibrosis area was significantly correlated with fibrosis stage as assessed by the Metavir score (rho = 0.733, P0.0001). The optimal cut-off value of fibrosis area was 1.6% for For = 2, 3.1% for For = 3, and 3.8-6.4% for F4. LS was significantly correlated with fibrosis stage (rho = 0.734, P0.0001). The optimal cut-off value of LS was 7.1 kPa for For = 2, 9.6 kPa for For = 3 and 11.6-16.9 kPa for F4. Multiple linear regression analysis selected fibrosis area (P = 0.0002), alanine aminotransferase (ALT) (P = 0.0237), gamma-glutamyltransferase (gamma-GTP) (P = 0.0114), prothrombin time (P = 0.0114) and hyaluronic acid (P0.0001) as factors correlating with LS.The correlation between LS and liver fibrosis was confirmed by the objective measurement of fibrosis area. ALT was significantly correlated with LS, suggesting that inflammatory activity also affects LS values. Despite some limitation, LS measurement is a useful method for the diagnosis of liver fibrosis. |
| Databáze: | OpenAIRE |
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