Mobilization of predominantly Philadelphia chromosome-negative blood progenitors using cyclophosphamide and rHUG-CSF in early chronic-phase chronic myeloid leukaemia: correlation with Sokal prognostic index and haematological control
| Autor: | R Herrmann, P Cannell, A Grigg, B. M. Dale, K Atkinson, Jeff Szer, David D.F. Ma, Timothy P. Hughes, J Ho, J E Norman, A P Schwarer, KM Taylor, R. E. Sage, Green Rm, C Arthur |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Philadelphia Chromosome Negative Hematopoietic stem cell transplantation Philadelphia chromosome Transplantation Autologous Gastroenterology Internal medicine Granulocyte Colony-Stimulating Factor medicine Humans Leukapheresis Aged business.industry Hematopoietic Stem Cell Transplantation Interferon-alpha Hematology Middle Aged Hematopoietic Stem Cells Prognosis medicine.disease Granulocyte colony-stimulating factor Regimen Treatment Outcome Leukemia Myeloid Chronic-Phase Immunology Female Sokal Score business medicine.drug |
| Zdroj: | British Journal of Haematology. 96:635-640 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1997.d01-2068.x |
| Popis: | Mobilization of Philadelphia chromosome (Ph) negative blood progenitors was attempted in 23 newly diagnosed chronic myeloid leukaemia (CML) patients using a regimen of cyclophosphamide (CY) 5 g/m 2 and rHUG-CSF 1150 μg/m 2 daily. This regimen was well tolerated with no major adverse events reported. More than 2 x 10 6 /kg CD34 + cells were collected in 21 patients (91%). Predominantly Ph-negative mobilization (0-25% Ph-positive) was seen in 30% of cases overall and was confined to patients with a Sokal prognostic score < 1 (7/11 with Sokal score |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text