Injectable Quercetin-Loaded Hydrogel with Cartilage-Protection and Immunomodulatory Properties for Articular Cartilage Repair
| Autor: | Weihan Yu, Yaohua He, Yanlun Zhu, Haiyan Li |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Chemistry Cartilage Inflammatory response Biochemistry (medical) Biomedical Engineering Injectable hydrogels Articular cartilage General Chemistry musculoskeletal system Biomaterials Extracellular matrix medicine.anatomical_structure medicine Articular cartilage repair Cartilage repair |
| Zdroj: | ACS applied bio materials. 3(2) |
| ISSN: | 2576-6422 |
| Popis: | Articular cartilage plays an important role in human body. How to repair articular cartilage defects when they appear due to various factors has always been a major clinical challenge. Recently, studies have shown that slowing the degradation of cartilage extracellular matrix (ECM) and modulating the inflammatory response of the host thereby promoting cartilage tissue regeneration are important in the cartilage repair process. In this study, a drug-loaded injectable hydrogel was constructed for repairing articular cartilage. This hydrogel could not only maintain the phenotype of chondrocytes but also regulate the inflammatory response of the host. The injectable sodium alginate (SA)/bioglass (BG) hydrogel was mixed with the injectable thermal-responsive SA/agarose (AG)/quercetin (Que) hydrogel to obtain an injectable hydrogel containing both Que and BG (Que-BG hydrogel) for articular cartilage regeneration. The Que-BG hydrogel has a proper swelling ratio that can promote integration between the formed tissue and host tissue, and it allows Que to release slowly |
| Databáze: | OpenAIRE |
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