Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone
| Autor: | Prerna Dogra, Robin Paudel, Jyoti Matta, Saurav Acharya, Saurav Suman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Drug
business.industry Ventricular Tachyarrhythmias media_common.quotation_subject lcsh:Medical emergencies. Critical care. Intensive care. First aid Case Report lcsh:RC86-88.9 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Amiodarone Case review 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Anesthesia Toxicity Medicine business Adverse effect Drug toxicity medicine.drug media_common Acute hepatitis |
| Zdroj: | Case Reports in Critical Care Case Reports in Critical Care, Vol 2016 (2016) |
| ISSN: | 2090-6439 2090-6420 |
| Popis: | Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication. The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form. |
| Databáze: | OpenAIRE |
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