Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy
| Autor: | J. von Pawel, C. Ewen, D. Tomita, U. Gatzemeier, Peter Johnson, Bernard Lebeau, G. Decoster, John Green, V. Trillet-Lenoir, Alain Depierre, Christian Manegold |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms Neutropenia Cyclophosphamide medicine.medical_treatment Placebo Gastroenterology Double-Blind Method Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor Humans Medicine Carcinoma Small Cell Etoposide Chemotherapy business.industry Bacterial Infections Middle Aged medicine.disease Recombinant Proteins Surgery Granulocyte colony-stimulating factor Lenograstim Oncology Doxorubicin Absolute neutrophil count Female business medicine.drug |
| Zdroj: | European Journal of Cancer. 29:319-324 |
| ISSN: | 0959-8049 |
| Popis: | The aim of this study was to determine the usefulness of recombinant human granulocyte colony stimulating factor (r-metHuG-CSF) following conventional chemotherapy for small cell lung cancer. 130 previously untreated patients were randomised to receive either r-metHuG-CSF (230 micrograms/m2) or placebo on days 4-17 following CDE (cyclophosphamide, doxorubicin and etoposide) chemotherapy. Over all cycles, 53% of 64 patients on placebo and only 26% of 65 patients on r-metHuG-CSF had at least one experience of neutropenia with fever defined as a neutrophil count less than 1.0 x 10(9)/l and a temperatureor = 38.2 degrees C (P0.002). It resulted in a reduction in the requirement for parenteral antibiotics from 58% in placebo patients compared with 37% in the r-metHuG-CSF group (P0.02), and a significant reduction in the incidence of infection-related hospitalisation. Chemotherapy doses were reduced by 15% or more at least once in 61% of the placebo group compared with 29% in the r-metHuG-CSF group (P0.001). 47% of the patients treated with placebo and 29% of the patients treated with r-metHuG-CSF experienced at least one cycle with a delay of 2 days or more in the administration of chemotherapy (P0.04). r-metHuG-CSF was well tolerated. There were no significant differences between the two groups in terms of response or survival. |
| Databáze: | OpenAIRE |
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