Genetic analysis of body weight in wild populations of medaka fish from different latitudes

Autor: Masaki Yasugi, Atsushi J. Nagano, Mana Nakatsukasa, Ai Shinomiya, Takashi Yoshimura, Tamiris I. Yassumoto
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Candidate gene
Physiology
Oryzias
Gene Expression
Genetic analysis
Biochemistry
0302 clinical medicine
Medicine and Health Sciences
Amino Acids
education.field_of_study
Multidisciplinary
Latitude
biology
Geography
Organic Compounds
Chemistry
Physiological Parameters
Physical Sciences
Freshwater fish
Medicine
Research Article
Fish Proteins
Cartography
Science
Population
Quantitative Trait Loci
Zoology
Single-nucleotide polymorphism
Quantitative trait locus
Research and Analysis Methods
Polymorphism
Single Nucleotide
Chromosomes
Molecular Genetics
03 medical and health sciences
Genetic variation
DNA-binding proteins
Genetics
Animals
Gene Regulation
Amino Acid Sequence
Allele
education
Molecular Biology Techniques
Molecular Biology
Alleles
Body Weight
Gene Mapping
Organic Chemistry
Chemical Compounds
Genetic Variation
Biology and Life Sciences
Proteins
biology.organism_classification
Regulatory Proteins
030104 developmental biology
Amino Acid Substitution
Genetic Loci
Earth Sciences
Sequence Alignment
030217 neurology & neurosurgery
Transcription Factors
Zdroj: PLoS ONE, Vol 15, Iss 6, p e0234803 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: The genetic bases of growth and body weight are of economic and scientific interest, and teleost fish models have proven useful in such investigations. The Oryzias latipes species complex (medaka) is an abundant freshwater fish in Japan and suitable for genetic studies. We compared two wild medaka stocks originating from different latitudes. The Maizuru population from higher latitudes weighed more than the Ginoza population. We investigated the genetic basis of body weight, using quantitative trait locus (QTL) analysis of the F2 offspring of these populations. We detected one statistically significant QTL for body weight on medaka chromosome 4 and identified 12 candidate genes that might be associated with body weight or growth. Nine of these 12 genes had at least one single nucleotide polymorphism that caused amino acid substitutions in protein-coding regions, and we estimated the effects of these substitutions. The present findings might contribute to the marker-assisted selection of economically important aquaculture species.
Databáze: OpenAIRE
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