Inflammasome Proteins in Cerebrospinal Fluid of Patients with Subarachnoid Hemorrhage are Biomarkers of Early Brain Injury and Functional Outcome
| Autor: | Qi Wu, Xin Zhang, Handong Wang, Xiaoliang Wang, Qing-Rong Zhang, Xiang-Sheng Zhang, Hao Pan, Qing Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Subarachnoid hemorrhage Inflammasomes Central nervous system Disease Gastroenterology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Risk Factors Internal medicine medicine Humans cardiovascular diseases Risk factor Aged Trauma Severity Indices business.industry NLRP1 Glasgow Outcome Scale Reproducibility of Results Inflammasome Recovery of Function Middle Aged Subarachnoid Hemorrhage medicine.disease Prognosis nervous system diseases 030104 developmental biology medicine.anatomical_structure Early Diagnosis Anesthesia Brain Injuries Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers medicine.drug |
| Zdroj: | World neurosurgery. 94 |
| ISSN: | 1878-8769 |
| Popis: | Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating disease with significant morbidity and mortality. To date, clinical variables are still used to evaluate injury severity and prognosis. This study was designed to investigate the role of cerebrospinal fluid (CSF) inflammasome proteins as laboratory-based biomarkers of brain injury severity and outcome in SAH patients.Ten control patients and 24 SAH patients were prospectively enrolled in this study. CSF samples were collected within 72 hours after SAH. Levels of inflammasome proteins in the CSF, including NLRP1, ASC, and caspase-1 were analyzed.Immunoblot analysis exhibited that levels of NLRP1, ASC and caspase-1 were elevated in the CSF of SAH patients (P0.0001, P = 0.0178, and P0.0001, respectively). In the group of SAH patients, these inflammasome proteins were significantly higher in the patients with cerebral edema on computed tomographic scans (P = 0.0002, P = 0.0005, and P = 0.0004, respectively), and in the patients with acute hydrocephalus (P = 0.0009, P = 0.00017, and P = 0.0016, respectively). Higher levels of inflammasome proteins were associated with severe SAH and poor outcome 3 months after the SAH. High level of NLRP1 was the independent risk factor of poor outcome after SAH (P = 0.049, odds ratio = 1.730).Inflammasome proteins are potential biomarkers to assess early brain injury and to predict functional outcome after SAH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect