Fluoroquinolones and risk of Achilles tendon disorders
| Autor: | Miriam C. J. M. Sturkenboom, Hubert G. M. Leufkens, P. D. Van Der Linden, R. M. C. Herings, B.H.Ch. Stricker |
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| Přispěvatelé: | Epidemiology and Data Science, Population-based studies of drug treatment: from molecule to patient outcomes, Universiteit Utrecht, Dep Farmaceutische wetenschappen |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Pediatrics Databases Factual Epidemiology Psychological intervention Biomedische technologie en medicijnen Achilles Tendon Farmacie/Biofarmaceutische wetenschappen (FARM) Tendinitis Risk Factors Medicine Humans Medical prescription Glucocorticoids General Environmental Science Aged Rupture Ziekenhuisstructuur en organisatie van de gezondheidszorg Achilles tendon business.industry General Engineering Case-control study Age Factors Farmacie(FARM) Drug Synergism General Medicine Middle Aged medicine.disease medicine.anatomical_structure Case-Control Studies Cohort Tendinopathy Papers Physical therapy General Earth and Planetary Sciences Female Public Health business Fluoroquinolones |
| Zdroj: | British Medical Journal, 324(7349), 1306-1307 Van der Linden, P D, Sturkenboom, M C J M, Herings, R M C, Leufkens, H G M & Stricker, B H C 2002, ' Fluoroquinolones and risk of Achilles tendon disorders : Case-control study ', British Medical Journal, vol. 324, no. 7349, pp. 1306-1307 . https://doi.org/10.1136/bmj.324.7349.1306 |
| ISSN: | 0959-8146 |
| Popis: | Fluoroquinolones have been associated with tendon disorders, usually during the first month of treatment,1–5 but the epidemiological evidence is scanty. We did a nested case-control study among users of fluoroquinolones in a large UK general practice database to study the association with Achilles tendon disorders. We obtained data from the IMS Health database (UK MediPlus), which contains data from general practice on consultations, morbidity, prescriptions, and other interventions in a source population of 1-2 million inhabitants. The base cohort consisted of all patients aged 18 years or over who had received a fluoroquinolone. We excluded people with a history of Achilles tendon disorders, cancer, AIDS, illicit drug use, or alcohol misuse. We identified potential cases by reviewing patient profiles and clinical data and excluded tendon disorders due to direct trauma. We randomly sampled a group of 10 000 control patients from the study cohort. We defined four categories of exposure to … |
| Databáze: | OpenAIRE |
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