Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study
| Autor: | Marios E. Daskalopoulos, Ιlias Tsagalas, Georgios I Tagarakis, Magda Tsolaki, Nikolaos Tsilimingas, Christos Voucharas, Charalampos Parisis, Eleni Gogaki, Fani Tsolaki, Vassilios Papaliagkas, Ιlias Sataitidis |
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| Jazyk: | angličtina |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Double blinded lcsh:Surgery Neuropsychological Tests behavioral disciplines and activities law.invention lcsh:RD78.3-87.3 Postoperative Complications Randomized controlled trial Double-Blind Method law mental disorders medicine Haloperidol Humans In patient Prospective Studies Cardiac Surgical Procedures Prospective cohort study Aged Aged 80 and over Analysis of Variance business.industry Delirium lcsh:RD1-811 General Medicine Ondansetron Cardiac surgery nervous system diseases lcsh:Anesthesiology Cardiothoracic surgery Anesthesia Female Surgery medicine.symptom business Cardiology and Cardiovascular Medicine medicine.drug Research Article |
| Zdroj: | Journal of Cardiothoracic Surgery Journal of Cardiothoracic Surgery, Vol 7, Iss 1, p 25 (2012) |
| ISSN: | 1749-8090 |
| DOI: | 10.1186/1749-8090-7-25 |
| Popis: | Background To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium. Methods We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.). Results Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. Discussion-Conclusions Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future. |
| Databáze: | OpenAIRE |
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