Resting Left Ventricular Global Longitudinal Strain to Identify Silent Myocardial Ischemia in Asymptomatic Patients with Diabetes Mellitus
| Autor: | Chloé Di Lena, Dan Rusinaru, Paul Gabrion, Yohann Bohbot, Quentin Delpierre, Grégoire Albenque, Dorothée Malaquin, Christophe Tribouilloy, Manon Bellaiche |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Myocardial Ischemia Context (language use) Left ventricular hypertrophy Asymptomatic Ventricular Function Left Coronary artery disease Ventricular Dysfunction Left Predictive Value of Tests Internal medicine Diabetes mellitus Diabetes Mellitus medicine Stress Echocardiography Humans Radiology Nuclear Medicine and imaging business.industry Stroke Volume Diabetic retinopathy medicine.disease Cardiology Dobutamine medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of the American Society of Echocardiography. 35:258-266 |
| ISSN: | 0894-7317 |
| Popis: | Screening for silent coronary artery disease in asymptomatic patients with diabetes mellitus (DM) is challenging and controversial. In this context, it seems crucial to identify early markers of coronary artery disease.The aim of this study was to investigate the incremental value of resting left ventricular (LV) global longitudinal strain (GLS) for the prediction of positive results on stress (exercise or dobutamine) transthoracic echocardiography in 273 consecutive asymptomatic high-risk patients with DM. Positive results on stress transthoracic echocardiography were defined as stress-induced LV wall motion abnormalities (new or worsening preexisting abnormalities).Compared with patients with negative stress results, those with positive stress results (n = 28 [10%]) more frequently had cardiovascular risk factors, complications of DM, vascular disease, moderate and severe calcification of the aortic valve and mitral annulus, and worse resting LV GLS (-16.7 ± 2.9% vs -19.0 ± 1.9%, P .001). On multivariable logistic regression analysis, DM duration10 years, diabetic retinopathy, LV hypertrophy, and impaired LV GLS (odds ratio, 1.39 [95% CI, 1.14-1.70] per percentage increase; odds ratio, 5.16 [95% CI, 1.96-13.59] for LV GLS worse than -18%) were independently associated with positive results on stress transthoracic echocardiography. The area under the curve to predict positive results was 0.74 for LV GLS with a cutoff of -18.0% (sensitivity 68%, specificity 78%). The area under the curve of the multivariable model to predict test results was improved by the addition of LV GLS (P .001), with a bias-corrected area under the curve after bootstrapping of 0.842 [95% CI, 0.753-0.893].The present findings show that resting LV GLS is associated with the presence of silent ischemia and could be useful to better identify asymptomatic patients with DM who might benefit from coronary artery disease screening. |
| Databáze: | OpenAIRE |
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