Immunohistochemical Analysis of Advanced Human Breast Carcinomas Reveals Downregulation of Protein Kinase Cα
| Autor: | Christopher Kerfoot, Susan A. Rotenberg, Weidong Huang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Protein Kinase C-alpha Histology Down-Regulation Breast Neoplasms PKC alpha 03 medical and health sciences Downregulation and upregulation Stroma Carcinoma medicine Humans Breast Mammary Glands Human Protein kinase A Protein Kinase C 030102 biochemistry & molecular biology biology medicine.disease Immunohistochemistry Staining 030104 developmental biology biology.protein Female Anatomy Antibody |
| Zdroj: | Journal of Histochemistry & Cytochemistry. 52:419-422 |
| ISSN: | 1551-5044 0022-1554 |
| Popis: | Forty-six advanced-stage human breast carcinoma specimens were evaluated by immunohistochemistry for PKCα expression and compared with 25 samples of normal adjacent breast tissue. For normal tissue, the median staining of ductal epithelia was of moderate intensity. No staining was observed for 67% of tumor specimens, and only 4% showed intensities greater than the median observed in normal tissue. Faint to moderate PKCα staining was observed in the stroma, inflammatory cells, and fibroblasts of tumors but was absent in normal tissue. These findings demonstrate that downregulation of PKCα protein occurs in epithelial cells of advanced breast tumors ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|