Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice

Autor:	Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires
Rok vydání:	2022
Předmět:	Arterioles Cerebrovascular Disorders Mice Physiology Physiology (medical) Cholinergic Agents Animals Estrogens Female Hyperemia Menopause Nitric Oxide Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 323:H845-H860
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00276.2022
Popis:	Cerebral parenchymal arterioles from menopause mice showed increased myogenic tone. We identified an impairment in smooth muscle cell BKCa channel activity, without a reduction in endothelium-dependent dilation or nitric oxide production. Microvascular dysfunction was associated with a reduction in neurovascular responses after somatosensory stimulation. Despite the neurovascular impairment, cognitive abilities were maintained in menopausal mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2731dbf0c5f8b8226f3b9d49617bf25 https://doi.org/10.1152/ajpheart.00276.2022 Zobrazit plný text záznamu