Hippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorder
| Autor: | Murad Atmaca, Zuhal Ozler, Bilge Kara, Ebru Kanmaz, Huseyin Ozdemir, Hanefi Yildirim, Ertan Tezcan, Sinan Ozler, Osman Mermi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder Refractory period Hippocampus Hippocampal formation behavioral disciplines and activities Amygdala Functional Laterality Neuroimaging mental disorders Basal ganglia medicine Humans Biological Psychiatry Pharmacology Analysis of Variance medicine.diagnostic_test Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging humanities medicine.anatomical_structure nervous system Case-Control Studies Female Psychology Neuroscience Anxiety disorder |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 32(5) |
| ISSN: | 0278-5846 |
| Popis: | Functional and structural neuroimaging studies have implicated the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD), although no consensus has been established. These brain regions have not been investigated in refractory OCD patients. Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in a sample of 14 refractory OCD patients and 14 healthy comparison subjects. The mean left and right hippocampal and amygdala volumes of the patients were smaller than those of the healthy controls. OCD severity was not correlated with amygdala volumes but was related to the left hippocampus. Duration of illness was correlated with both hippocampus and left amygdala. Our findings suggest that hippocampus and amygdalar abnormalities can be considered in refractoriness to OCD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect