Clinical and immunological pattern and outcome of Egyptian systemic lupus erythematosus patients: a single center experience
| Autor: | B M Eissa, Geilan A. Mahmoud, Hania S. Zayed, Amira A. Shahin, Abdelkawy Moghazy |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Disease outcome 030204 cardiovascular system & hematology Single Center Outcome (game theory) 03 medical and health sciences Antimalarials Young Adult 0302 clinical medicine Rheumatology Internal medicine Azathioprine medicine Humans Lupus Erythematosus Systemic Child Glucocorticoids Retrospective Studies 030203 arthritis & rheumatology business.industry Middle Aged Child Preschool Prednisone Egypt Female business Immunosuppressive Agents |
| Zdroj: | Lupus. 27(9) |
| ISSN: | 1477-0962 |
| Popis: | Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002–2015 at Kasr Alainy Hospital, Cairo University, were retrospectively reviewed. Results There were 707 (91.8%) females. The mean age at disease onset was 22.1 ± 8.6 and the disease duration was 6.1 ± 4.5 years. The main clinical manifestations were mucocutaneous (90.8% with oral ulcers affecting 52.5%), arthritis (80.3%), nephritis (67.8%), hematologic involvement (64.9%), serositis (55.2%) and neuropsychiatric manifestations (44.3%). The frequencies of antinuclear antibodies were 94.3%, anti-dsDNA 74.8%, anti-Smith 11%, anticardiolipin antibodies 29.5% and lupus anticoagulant 19.8%. Infections, predominantly bacterial, affected 337 (43.8%) patients. Thirty-three (4.3%) patients died. The main causes of death were sepsis and disease activity. The five- and 10-year survival rates for the total cohort were 97.4% and 96.3%, respectively, and were 96% and 92%, respectively for those with nephritis ( p = 0.008). Autoimmune hemolytic anemia, thrombocytopenia, elevated serum creatinine, a higher damage index, infections, a higher glucocorticoid dose and cyclophosphamide use ≥ six months were associated with an increased risk of mortality with odds ratios of 3.69, p Conclusion Compared to other cohorts, a relatively lower mean age at systemic lupus erythematosus onset and higher frequencies of oral ulcers, serositis and nephritis were found. |
| Databáze: | OpenAIRE |
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