Examination of a deformable motion model for respiratory movements and 4D dose calculations using different driving surrogates
| Autor: | Jens Wölfelschneider, Christoph Bert, Matteo Seregni, Aurora Fassi, Marc Ziegler, Rainer Fietkau, Marco Riboldi, Guido Baroni |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Lung Neoplasms
Dose calculation Image quality Motion (geometry) Scale-invariant feature transform Image registration Standard deviation 030218 nuclear medicine & medical imaging 4D dose reconstruction Motion 03 medical and health sciences 0302 clinical medicine Humans 4DCT respiratory motion model scale invariant feature transform surrogates Four-Dimensional Computed Tomography Radiometry Mathematics Radiotherapy Planning Computer-Assisted Respiration General Medicine Intensity (physics) Amplitude 030220 oncology & carcinogenesis Artifacts Biomedical engineering |
| Popis: | Purpose The aim of this study was to evaluate a surrogate-driven motion model based on four-dimensional computed tomography that is able to predict CT volumes corresponding to arbitrary respiratory phases. Furthermore, the comparison of three different driving surrogates is examined and the feasibility of using the model for 4D dose re-calculation will be discussed. Methods The study is based on repeated 4DCTs of twenty patients treated for bronchial carcinoma and metastasis. The motion model was estimated from the planning 4DCT through deformable image registration. To predict a certain phase of a follow-up 4DCT, the model considers inter-fractional variations (baseline correction) and intra-fractional respiratory parameters (amplitude and phase) derived from surrogates. The estimated volumes resulting from the model were compared to ground-truth clinical 4DCTs using absolute HU differences in the lung region and landmarks localized using the Scale Invariant Feature Transform. Finally, the γ-index was used to evaluate the dosimetric effects of the intensity differences measured between the estimated and the ground-truth CT volumes. Results The results show absolute HU differences between estimated and ground-truth images with median value (± standard deviation) of (61.3 ± 16.7) HU. Median 3D distances, measured on about 400 matching landmarks in each volume, were (2.9 ± 3.0) mm. 3D errors up to 28.2 mm were found for CT images with artifacts or reduced quality. Pass rates for all surrogate approaches were above 98.9% with a γ-criterion of 2%/2 mm. Conclusion The results depend mainly on the image quality of the initial 4DCT and the deformable image registration. All investigated surrogates can be used to estimate follow-up 4DCT phases, however, uncertainties decrease for volumetric approaches. Application of the model for 4D dose calculations is feasible. |
| Databáze: | OpenAIRE |
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