BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis
| Autor: | Kashmira Kulkarni-Datar, Tom Brown, Sanjay K. Srivastava, Ravi P. Sahu, Christina A. Wicker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Microarray
business.industry Cruciferous vegetables Benzyl isothiocyanate Cancer General Medicine Cell cycle medicine.disease Bioinformatics lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 medicine.anatomical_structure Apoptosis Cancer research Medicine Adenocarcinoma business Sensitization |
| Zdroj: | Cancer Growth and Metastasis, Vol 2 (2009) Cancer Growth and Metastasis, Vol 2009, Iss 2, Pp 45-55 (2010) |
| ISSN: | 1179-0644 |
| Popis: | Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is often associated with mutations in codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Codon 12 mutations maintain Ras in a constitutively active state leading to continuous cellular proliferation. Our study determined if TRAIL resistance in pancreatic adenocarcinomas with K-Ras 12 mutations could be overcome by first sensitizing the cells with Benzyl isothiocyanate (BITC). BITC is a component of cruciferous vegetables and a cell cycle inhibitor. BxPC3, MiaPaCa2 and Panc-1 human pancreatic adenocarcinoma cell lines were examined for TRAIL resistance. Our studies show BITC induced TRAIL sensitization by dual activation of both the extrinsic and intrinsic apoptotic pathways. |
| Databáze: | OpenAIRE |
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